The idea of a non-ligating bracket system first started in 2010 when Innobrace Orthodontics wanted to create a novel approach that uses a unique flexible engagement system to hold the arch wire in place unlike any commercially available bracket system. This novel design is specially designed to save time for orthodontists, yield better treatment efficiency and increase comfort for the patients. In 2010, Dr. Atsushi Danno, a PE-COI (Precision Engineering Centre of Innovation) senior consultant of Singapore Institute of Manufacturing Technology (SIMTech) – a research institute of the Agency for Science, Technology and Research (A*STAR) -introduced a special titanium alloy to Innobrace for the flexible engagement system of the bracket. The special titanium alloy with low elastic modulus and good mechanical properties were found suitable for the flexing concept in the novel non-ligating bracket design. This started the feasibility study to assess the forming process of the special titanium alloy non-ligating brackets. With the support of A*STAR’s “Get-Up Programme“, three SIMTech staff were attached to Innobrace full-time to assist the company on developing this new innovative non-ligating bracket system. After the successful completion of the phase one project, the innovation and commercialization value was recognized by SPRING Singapore and the Capability Development Grant (CDG) was awarded to Innobrace Orthodontics Pte Ltd in 2011 to continue the collaboration with SIMTech to pursue commercialization of the innovative non-ligating bracket design. SIMTech provided technical know-how and consultation to Innobrace through simulation, design and process development. With the simulation data, Innobrace was able to modify and improve further on the design of the non-ligating bracket system. The final design of the non-ligating brackets was finalized in 2012 and SIMTech continues to assist Innobrace in establishing manufacturing processes and transferring technical know-how for commercialisation. .